MSI PARENTERAL PARECOXIB FOLLOWED BY ORAL VALDECOXIB AFTER MAJOR GENERAL SURGERY REDUCES OPIOID CONSUMPTION AND OPIOID-RELATED SYMPTOMS
نویسندگان
چکیده
منابع مشابه
Effects of parecoxib on postoperative pain and opioid-related symptoms following gynecologic surgery
OBJECTIVE To examine the analgesic and opioid-sparing effects of parecoxib following major gynecologic surgery. METHODS This is a large subset analysis of patients from a multicenter, randomized, double-blind, placebo-controlled study of parecoxib/valdecoxib (PAR/VAL) for postoperative pain. Pain severity, pain interference with function, opioid use, occurrence of opioid-related symptoms, and...
متن کاملSafety and efficacy of the cyclooxygenase-2 inhibitors parecoxib and valdecoxib after noncardiac surgery.
BACKGROUND Valdecoxib and its intravenous prodrug parecoxib are reported to increase thromboembolic risk after coronary artery bypass grafting. The authors conducted a randomized trial to examine their safety and analgesic efficacy in patients recovering from major noncardiac surgical procedures. METHODS The trial was randomized and double-blind, with 10 days of treatment and 30 days of follo...
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PURPOSE Parecoxib provides analgesia following a variety of surgeries, including minor gastrointestinal procedures. To our knowledge, there is no data on parecoxib following major gastrointestinal surgery. This study assessed the efficacy and opioid-sparing effects of parecoxib following major gastrointestinal surgeries. PATIENTS AND METHODS Patients in this analysis were a subset from a larg...
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Postoperative pain management is one of the most challenging jobs in orthopedic surgical population as it comprises of patients from extremes of ages and with multiple comorbidities. Though effective, opioids may contribute to serious adverse effects particularly in old age patients. Intravenous paracetamol is widely used in the postoperative period with the hope that it may reduce opioid consu...
متن کاملS(+)-ketamine as an analgesic adjunct reduces opioid consumption after cardiac surgery.
There are no studies evaluating S(+)-ketamine for pain management after sternotomy. In this prospective, randomized, double-blind, placebo-controlled clinical trial, we evaluated the efficacy and feasibility of S(+)-ketamine as an adjunctive analgesic after cardiac surgery. Ninety patients scheduled for elective coronary artery bypass grafting (CABG) were randomized to receive either a 75 micro...
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ژورنال
عنوان ژورنال: Value in Health
سال: 2005
ISSN: 1098-3015
DOI: 10.1016/s1098-3015(10)62582-x